Recurrent Sepsis Caused by Streptococcus pyogenes

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Molecular Analysis of an Outbreak of Lethal Postpartum Sepsis Caused by Streptococcus pyogenes

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HMGB1 in severe soft tissue infections caused by Streptococcus pyogenes

Extracellular High Mobility Group Box 1 (HMGB1) has been associated with acute and chronic inflammatory conditions. However, little is known about HMGB1 in necrotizing bacterial infections. We hypothesized that the local HMGB1 response is excessive in severe soft tissue infections (STIs), which are characterized by necrosis and hyperinflammation. To explore this, tissue biopsies were collected ...

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ژورنال

عنوان ژورنال: Journal of Clinical Microbiology

سال: 2011

ISSN: 0095-1137

DOI: 10.1128/jcm.02378-10